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1. The dechlorination rates of six haloethanes were investigated in vitro, using liver microsomes derived from rats treated with Aroclor 1254. 2. The compounds studied were 1,1-dichloroethane, 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2,2-tetrachloroethane, 1,1,1-trifluoro-2-chloroethane and hexachloroethane. 3. Dechlorination kinetics (Km and Vmax) were measured at various substrate concentrations. 4. Electron densities in the molecules for which dechlorination data are available were calculated by the MINDO/3 method. 5. A previously reported correlation between electronic parameters and dechlorination rate was not confirmed, but rather a separate relationship between these parameters for each of three structural classes (RCH2Cl, RCHCl2 and RCCl3) was observed. 6. On the basis of these observations, possible reaction mechanisms and their toxicological implications are discussed.
A G Salmon, and
R B Jones, and
W C Mackrodt
February 1971,
Biochemical pharmacology,
A G Salmon, and
R B Jones, and
W C Mackrodt
January 1984,
European journal of drug metabolism and pharmacokinetics,
A G Salmon, and
R B Jones, and
W C Mackrodt
November 1975,
Molecular pharmacology,
A G Salmon, and
R B Jones, and
W C Mackrodt
January 1973,
Annals of the New York Academy of Sciences,
A G Salmon, and
R B Jones, and
W C Mackrodt
August 1973,
Biochemical and biophysical research communications,
A G Salmon, and
R B Jones, and
W C Mackrodt
December 1979,
Veterinary and human toxicology,
A G Salmon, and
R B Jones, and
W C Mackrodt
December 2018,
ACS omega,
A G Salmon, and
R B Jones, and
W C Mackrodt
December 2022,
Journal of the American Chemical Society,
A G Salmon, and
R B Jones, and
W C Mackrodt
January 2010,
Chemistry (Weinheim an der Bergstrasse, Germany),
A G Salmon, and
R B Jones, and
W C Mackrodt
May 1973,
Journal of the National Cancer Institute,
