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The adsorption of the antiepileptics sulthiame, phenytoin, mephenytoin, mesuximide, phensuximide, ethosuximide, and primidone on various antacids or adsorbents was studied at 37 degrees C. The antacids or adsorbents used were magnesium trisilicate, aluminium hydroxide, bismuth oxidcarbonate, magnesium oxide, talc, kaolin and calcium carbonate. Magnesium trisilicate was found to be the strongest adsorbent for most of the antiepileptics tested. The other antacids or adsorbents were without an appreciable effect. Sulthiame exhibited the highest degree of interaction with magnesium trisilicate. Mesuximide, phensuximide and primidone showed intermediate adsorption properties. Mephenytoin and phenytoin had lower adsorption characters, while ethosuximide was the least adsorbed antiepileptic tested. The extent of elution was found to be inversely proportional to adsorption. Alkaline solution gave relatively higher eluting power than acid solution. The mechanism of adsorption of the various antiepileptics on antacids was discussed. The effect of magnesium trisilicate on the bioavailability of coadministered antiepileptics has still to be confirmed by in vivo testing.
V F Naggar, and
S A Khalil
February 1973,
Die Pharmazie,
V F Naggar, and
S A Khalil
February 1965,
Journal of pharmaceutical sciences,
V F Naggar, and
S A Khalil
November 1981,
American journal of hospital pharmacy,
V F Naggar, and
S A Khalil
October 1996,
Ancient science of life,
V F Naggar, and
S A Khalil
August 1992,
The Journal of pharmacy and pharmacology,
V F Naggar, and
S A Khalil
November 1958,
Journal of the American Pharmaceutical Association. American Pharmaceutical Association,
V F Naggar, and
S A Khalil
January 1987,
Clinical therapeutics,
V F Naggar, and
S A Khalil
January 1988,
Bollettino della Societa italiana di biologia sperimentale,
V F Naggar, and
S A Khalil
June 1983,
East African medical journal,
V F Naggar, and
S A Khalil
January 1984,
Pharmaceutica acta Helvetiae,
