Biomaterial Database

[Experimental autoradiographic study on the proliferation kinetics of the ischemically injured rat small intestine]. 1981

K Günther, and D Kranz

The kinetics of proliferation of the ischemically injured small intestine in rats were tested after recovery of the circulation in dependence on the age by means of the autoradiography. The marking index and the middle density of silver grain were applied. The time of the anoxia amounted to 3 hours, since in that case a regeneration can hardly be expected after this time. With a complete regeneration both the number of the synthesizing cells and the synthesized DNA quantity can be calculated after the recovery of circulation. Differences dependent on the age become clear, in a similar way to the physiological kinetics of proliferation. The values of comparison with the control group are reached in rats at an age of 6 weeks already after nearly 18 to 20 hours. On the other hand the time of the regeneration amounted to nearly 36 to 48 hours in the rats at the age of 12 months. The demand of an early diagnosis and recovery of the circulation within 3 hours is emphasized.

UI	MeSH Term	Description	Entries
D007421	Intestine, Small	The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.	Small Intestine,Intestines, Small,Small Intestines
D007511	Ischemia	A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	Ischemias
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008297	Male		Males
D012038	Regeneration	The physiological renewal, repair, or replacement of tissue.	Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001345	Autoradiography	The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)	Radioautography
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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