-transparent.png){kind=logo}
Platelet-activating factor (PAF-acether), a mediator of anaphylaxis and inflammation, is a 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine. Some analogs of PAF-acether were prepared by total synthesis or by partial synthesis from commercially available phospholipids and tested for platelet aggregating activity. This study indicated that the ether linkage at the position 1 of sn-glycerol and the short acyl chain at position 2 are structural features required for biological activity.
Related Publications
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1981,
Biochimie,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
December 1982,
Agents and actions,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1989,
Advances in prostaglandin, thromboxane, and leukotriene research,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1986,
Bulletin europeen de physiopathologie respiratoire,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
December 1981,
Agents and actions,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1985,
Die Pharmazie,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1988,
Progress in clinical and biological research,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
M Ténce, and
E Michel, and
E Coeffier, and
J Polonsky, and
J J Godfroid, and
J Benveniste
December 1980,
Agents and actions,
