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Several drugs are known to interfere in thyroid hormone metabolism: 1) They can affect directly and specifically T4 to T3 conversion. This can be observed in vivo and in vitro. In vivo serum T3 concentrations will decrease and rT3 concentrations increase. Amiodarone, other iodinated compounds (cholecystographic agents: ipodate and iopanoic acid), propylthiouracil and propranolol are known to act in this way. 2) Other drugs which induce the hepatic capacity to catabolize drugs will also affect thyroid hormone metabolism, e.g. diphenylhydantoine. Clinically, inhibitors of conversion will increase serum total and free T4, however this finding per se does not proof hyperthyroidism as in some cases serum TSH will increase after i.v. injection of 400 micrograms TRH. Furthermore the increase in serum T4 can be explained in part by a low metabolic clearance rate, T4 production being barely increased.
A G Burger, and
M Lambert, and
M Cullen
July 1977,
Clinica chimica acta; international journal of clinical chemistry,
A G Burger, and
M Lambert, and
M Cullen
June 1975,
Nuclear-Medizin,
A G Burger, and
M Lambert, and
M Cullen
March 1985,
Endocrinologia experimentalis,
A G Burger, and
M Lambert, and
M Cullen
January 1976,
Endocrinologie,
A G Burger, and
M Lambert, and
M Cullen
November 1978,
Clinica chimica acta; international journal of clinical chemistry,
A G Burger, and
M Lambert, and
M Cullen
October 1984,
Molecular and cellular endocrinology,
A G Burger, and
M Lambert, and
M Cullen
July 1978,
Acta endocrinologica,
A G Burger, and
M Lambert, and
M Cullen
March 1978,
Bollettino della Societa italiana di biologia sperimentale,
A G Burger, and
M Lambert, and
M Cullen
January 1978,
Annales d'endocrinologie,
A G Burger, and
M Lambert, and
M Cullen
November 1984,
Acta endocrinologica,
