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The role of the complement system was studied in Na-taurocholate pancreatitis in rats. Complement activity (CH 50) was determined at various times in the course of pancreatitis. Immediately after induction of acute pancreatitis, serum complement activity declined and massive C 3 deposits could be detected in the vicinity of acinar necroses and necrobioses. After a phase of recovery three to six hours postoperatively a second complement consumption occurred. Lethality rate increased as serum complement activity fell below 50% of preoperative values. The degree of C 3 deposition increased up to six hours. Decline of serum complement activity and deposition within the pancreas seemed to be correlated with histologically demonstrable tissue lesion. The first decline of complement activity in serum is thought to be caused by liberation of complement activating substances within the pancreas due to the detergent action of Na-taurocholate itself. The second decline, however, may be due to the liberation of complement activating and/or destroying enzymes into the blood stream.
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1980,
Scandinavian journal of gastroenterology,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1984,
Experimental pathology,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
August 1995,
The Journal of surgical research,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1983,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1980,
Scandinavian journal of gastroenterology,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1986,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
January 1980,
Scandinavian journal of gastroenterology,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
February 1991,
The American journal of physiology,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
October 2013,
Digestive diseases and sciences,
R Seelig, and
P G Lankisch, and
H Koop, and
K Winckler, and
U Kaboth, and
H P Seelig
September 2007,
JOP : Journal of the pancreas,
