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Animal experiments illustrating the effects of coronary artery disease are described. These experiments show marked blunting of reactive hyperremia with 80% of narrowing, and markedly decreased resting blood flow with 90% narrowing of the coronary artery. With 60% stenosis, blunting of hyperemic response occurs with a 5 mm long stenosis and decreased resting blood flow with a 10 mm long stenosis. Further reduction of resting blood flow is demonstrated with serial narrowing. In 6 patients with variant angina, resting myocardial blood flow decreased during episodes of spontaneous angina. Similar results were found in 13 patients with variant angina after ergonovine administration.
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