Two cases of calcification of Striopallidodentate System will be considered. The first refers to a 20-years-old patient and features two small bilateral and symmetrical calcifications in the medial segment of globus pallidum. The first symptom, observed from the age 5 years was, behaviour disorder and, some years later, dystonia. The second case refers to a 54-years-old patient and features huge bilateral and symmetrical calcifications above and below the tentorium. The first symptoms started at the age of 32 with paraesthesiae and muscular contractions of the upper limbs, later with convulsive seizures and tetany and eventually right hemiplegia with aphasia. Study of Ca and P metabolism showed normoparathyroidism in the first case and idiopathic hypoparathyroidism in the second.