Biomaterial Database

The effects upon urinary excretion of distension of the isolated pulmonary arteries in anaesthetized dogs. 1981

W O Kan, and J R Ledsome

1. The experiments were carried out to determine whether localized pulmonary arterial distension caused changes in the renal excretion of water and solutes. 2. When pulmonary arterial pouch pressure was maintained constant at low pressure 0.5-1.6 KPa (4-12 mm Hg) urinary excretion of sodium remained relatively constant over a period of 110 min. 3. Increasing pulmonary arterial pouch pressure by 3.6 KPa (27 mm Hg) did not cause changes in systemic pressure or solute excretion. Increasing pulmonary arterial pouch pressure by 6.7 KPa (50 mm Hg) increased systemic arterial pressure and caused a small increase in sodium excretion. 4. In dogs prepared in similar fashion but with one kidney totally isolated and perfused at constant pressure, increasing pulmonary arterial pouch pressure by 9.3 KPa (70 mm Hg), increased systemic arterial pressure, osmolal clearance and solute excretion from the intact kidney. There were no changes in urinary excretion from the isolated perfused kidney. 5. The increase in solute excretion associated with pulmonary arterial distension is most likely to be due to haemodynamic effects on the kidney possible accompanied by changes in renal nerve activity.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D009318	Natriuresis	Sodium excretion by URINATION.	Natriureses
D011311	Pressoreceptors	Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.	Baroreceptors,Receptors, Stretch, Arterial,Receptors, Stretch, Vascular,Stretch Receptors, Arterial,Stretch Receptors, Vascular,Arterial Stretch Receptor,Arterial Stretch Receptors,Baroreceptor,Pressoreceptor,Receptor, Arterial Stretch,Receptor, Vascular Stretch,Receptors, Arterial Stretch,Receptors, Vascular Stretch,Stretch Receptor, Arterial,Stretch Receptor, Vascular,Vascular Stretch Receptor,Vascular Stretch Receptors
D011651	Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.	Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D000768	Anesthesia, General	Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.	Anesthesias, General,General Anesthesia,General Anesthesias