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Blood oxygen transport function was studied in 40 patients with ischemic heart disease and afflicted or intact cardiac coronary arteries (as demonstrated by angiography) and in 23 individuals of the control group. Analysis of indices characterizing oxygen transport in patients with ischemic heart disease revealed diminished affinity of hemoglobin for oxygen with a shift of the oxyhemoglobin dissociation curve to the right and downward. The shift of the oxyhemoglobin dissociation curve is due a decrease in blood pH and increase of the role of auxiliary factors, 2,3-diphosphoglycerate in patricular. The shifts in the curve were more marked in patients with poor physical load tolerance and affliction of the three main coronary arteries, which is an act of compensation aimed at improving oxygenation of the heart muscle.
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