Biomaterial Database

Increased heart rate response to parasympathetic and beta adrenergic blockade in growth-retarded fetal lambs. 1980

A J Llanos, and J R Green, and R K Creasy, and A M Rudolph

To determine the influence of the autonomic nervous system on the circulation of normal and growth-retarded fetal lambs we measured the responses of heart rate and arterial blood pressure to parasympathetic (atropine 0.2 mg/kg) and beta-adrenergic (propranolol 1.0 mg/kg) blockade in the last quarter of gestation. The heart rate response to parasympathetic blockade increased with gestational age in both normal and growth-retarded fetuses but in the growth-retarded fetuses there was a significantly greater response to parasympathetic blockade than in control fetuses from 121 days' gestation to term. The heart rate response to beta-adrenergic blockade did not change with gestational age in normal fetuses. From 131 days' gestation to term the heart rate response to beta-adrenergic blockade in growth-retarded fetuses was significantly higher than in normal fetuses. The systemic arterial blood pressure responses to parasympathetic or beta-adrenergic blockade were similar in growth-retarded and normal fetuses. These results indicate an increased parasympathetic and beta-adrenergic influence on the heart of fetuses whose growth has been retarded. It may also suggest a more generalized increase in parasympathetic and sympathetic tone affecting other organs and systems in the growth-retarded fetal lambs.

UI	MeSH Term	Description	Entries
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011433	Propranolol	A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.	Dexpropranolol,AY-20694,Anaprilin,Anapriline,Avlocardyl,Betadren,Dociton,Inderal,Obsidan,Obzidan,Propanolol,Propranolol Hydrochloride,Rexigen,AY 20694,AY20694,Hydrochloride, Propranolol
D001784	Blood Gas Analysis	Measurement of oxygen and carbon dioxide in the blood.	Analysis, Blood Gas,Analyses, Blood Gas,Blood Gas Analyses,Gas Analyses, Blood,Gas Analysis, Blood
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D005260	Female		Females
D005317	Fetal Growth Retardation	Failure of a FETUS to attain expected GROWTH.	Growth Retardation, Intrauterine,Intrauterine Growth Retardation,Fetal Growth Restriction,Intrauterine Growth Restriction
D005318	Fetal Heart	The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.	Fetal Hearts,Heart, Fetal,Hearts, Fetal
D005865	Gestational Age	The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination.	Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages