Biomaterial Database

Observations on the 2,4-dichlorophenoxyacetic acid (2,4-D) excretion in the goat. 1980

J Orberg

The protein binding of 2,4-D in goat plasma was studied by means of equilibrium dialysis and the renal excretion of 2,4-D in three female goats by means of clearance methods. At low plasma levels of 2,4-D (less than 20 microgram/ml) about 97% of 2,4-D is bound to plasma proteins. The fraction of 2,4-D bound to plasma proteins decreases with rising plasma 2,4-D concentrations. A tubular secretion mechanism for 2,4-D, with a Tm value of about 9 mg (40 mumol)/min., is demonstrated. The contribution from the tubules to the 2,4-D excreted per minute is greater than 97% at a plasma 2,4-D level of 10 microgram/ml. At moderate and high plasma 2,4-D concentrations (greater than 40 microgram/ml) the inulin clearance decreases with rising plasma 2,4-D concentrations.

UI	MeSH Term	Description	Entries
D007444	Inulin	A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D001798	Blood Proteins	Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.	Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D005260	Female		Females
D005919	Glomerular Filtration Rate	The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.	Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006041	Goats	Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.	Capra,Capras,Goat
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015084	2,4-Dichlorophenoxyacetic Acid	An herbicide with irritant effects on the eye and the gastrointestinal system.	2,4-D,2,4-Dichlorophenoxyacetic Acid, Ammonium Salt,2,4-Dichlorophenoxyacetic Acid, Lithium Salt,2,4-Dichlorophenoxyacetic Acid, Potassium Salt,2,4-Dichlorophenoxyacetic Acid, Sodium Salt,Monosan,2,4 Dichlorophenoxyacetic Acid