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Using a short-lived isotope of zinc (69mZn) with a half-life of 13.9 hr, we have developed a simple test of zinc absorption. After an oral dose of isotope (50 muCi) with 2 mg of elemental zinc a plasma appearance curve was constructed from radioactivity determined in blood samples taken sequentially over 8 hr. Two week later an iv dose of isotope (25 muCi) was administered and a plasma disappearance curve was constructed. Absorption was calculated by computer analysis of appearance and disappearance curves using a deconvolution programme. Mean absorption in five normal subjects was 61% (range 41 to 79%). In three subjects given food with, or 1 hr before the isotope, absorption was delayed and reduced to less than 20% of the oral dose at 8 hr. This test of zinc absorption is simple to perform and, because the isotope has a short half-life, has the advantage of subjecting patients to only limited radiation.
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
November 1981,
Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
March 2002,
American journal of physiology. Endocrinology and metabolism,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
May 1987,
Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
September 1982,
The American journal of clinical nutrition,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
November 1967,
The British journal of radiology,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
January 1997,
Biomedizinische Technik. Biomedical engineering,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
April 2022,
Rapid communications in mass spectrometry : RCM,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
December 2001,
European journal of clinical nutrition,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
May 1986,
British journal of clinical pharmacology,
M Molokhia, and
G Sturniolo, and
R Shields, and
L A Turnberg
May 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
