Biomaterial Database

An easy method of calculating approximate recurrence risks using a multifactorial model of disease transmission. 1980

T P Hutchinson

In the usual form of the multifactorial model of disease transmission, calculation of recurrence risks is made difficult by the necessity to evaluate integrals involving the Normal distribution. It is suggested here that this becomes much easier if the Normal distribution is replaced by the Pareto distribution. Tables are given systematically comparing values of recurrence risk calculated on the Normal and Pareto models when information about two or three first degree relatives is available. Also, a more complicated pedigree is examined. It is shown from these comparisons that the Pareto model gives very similar results to the Normal model.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008957	Models, Genetic	Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.	Genetic Models,Genetic Model,Model, Genetic
D011336	Probability	The study of chance processes or the relative frequency characterizing a chance process.	Probabilities
D012008	Recurrence	The return of a sign, symptom, or disease after a remission.	Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012306	Risk	The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.	Relative Risk,Relative Risks,Risk, Relative,Risks,Risks, Relative
D030342	Genetic Diseases, Inborn	Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.	Hereditary Diseases,Genetic Diseases,Genetic Disorders,Hereditary Disease,Inborn Genetic Diseases,Single-Gene Defects,Defect, Single-Gene,Defects, Single-Gene,Disease, Genetic,Disease, Hereditary,Disease, Inborn Genetic,Diseases, Genetic,Diseases, Hereditary,Diseases, Inborn Genetic,Disorder, Genetic,Disorders, Genetic,Genetic Disease,Genetic Disease, Inborn,Genetic Disorder,Inborn Genetic Disease,Single Gene Defects,Single-Gene Defect