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The absorption of timolol after topical administration to the eye was studied in 11 healthy volunteers and in 5 patients with bilateral open angle glaucoma. The volunteers received 2 drops of 0.5% timolol ophthalmic solution in each eye, equivalent to 0.8 mg of timolol maleate. Overflow was absorbed by paper tissue. The patients received the same dose twice daily for 2 weeks and were then investigated. In the paper tissue, 12 to 88% of the dose administered was recovered. Plasma concentrations were never above 5 ng/ml and not always detectable (detection limit 1 to 2 ng/ml). However, timolol was absorbed as the drug was found in the urine samples from all volunteers and glaucomatous patients.
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
January 1988,
Journal of ocular pharmacology,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
January 1985,
Journal of ocular pharmacology,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
January 1991,
Journal of ocular pharmacology,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
September 1990,
Investigative ophthalmology & visual science,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
September 1994,
Pharmaceutical research,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
January 1993,
British journal of hospital medicine,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
October 2010,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
December 1979,
Postgraduate medical journal,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
January 1986,
JAMA,
G Alvan, and
B Calissendorff, and
P Seideman, and
K Widmark, and
G Widmark
October 1983,
American journal of ophthalmology,
