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This study was conducted to determine the effects of clofilium phosphate and bretylium tosylate on ventricular defibrillation threshold. Dogs were anesthetized with pentobarbital and subjected to repeated fibrillation-defibrillation episodes. Defibrillation thresholds were determined at 15-min intervals, using underdamped 5--6 msec sinusoidal current shocks, from 30 min before drug injection to 120 min after injection. Eight dogs were given clofilium phosphate (0.34 mg/kg, iv). Another 10 dogs were given bretylium tosylate (10.0 mg/kg, iv). Both drugs lowered defibrillation threshold from 15--90 min after injection. The maximum clofilium effect was a 31% decrease in threshold current and a 54% decrease in threshold energy. The greatest decrease in defibrillation threshold produced by bretylium was 16% for current and 31% for energy. These drug induced changes in defibrillation threshold are of potential clinical benefit if they occur in human subjects at doses which are effective for control of ventricular arrhythmias.
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
September 1979,
American heart journal,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
May 1981,
Critical care medicine,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
November 1986,
The West Virginia medical journal,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
January 2001,
Indian heart journal,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
October 1978,
Pacing and clinical electrophysiology : PACE,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
March 1988,
The Medical clinics of North America,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
April 1979,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
April 1981,
The Western journal of medicine,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
April 1992,
Pacing and clinical electrophysiology : PACE,
W A Tacker, and
M J Niebauer, and
C F Babbs, and
W J Combs, and
B M Hahn, and
M A Barker, and
J F Seipel, and
J D Bourland, and
L A Geddes
January 1988,
Pacing and clinical electrophysiology : PACE,
