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Three cases of non-traumatic perforation of the common bile duct are reported. Severe inflammatory reaction of the perforated site was a common and only histologic finding in those three patients. Timely diagnosis of the resulting choloperitoneum and prompt surgical treatment of the primary cause of biliary inflammation afforded long-term uncomplicated cure; the site of perforation healed spontaneously after simple external drainage of the newly formed bile cavity.
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