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In 12 patients with obstructive respiratory tract disease there occurred a decrease in the mean respiratory tract resistance of maximally 37% and a fall in pulmonary artery pressure of maximally 28% six hours after oral administration of 700 mg theophylline-ethylenediamine (Aminophyllin retard). The effect lasted beyond the 12 hours of observation on the first day and, after 14-day administration of twice daily 350 mg, remained nearly unchanged. After two weeks there was a clinically significant increase in vital capacity averaging 13%, the residual volume decreased by 14%.
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