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A multiple dose schedule of antibiotic administration parallels the clinical therapeutic situation. However, most reported studies on the aqueous humor concentration of antibiotics have been carried out following single doses of drug. We administered 2 penicillinase-resistant penicillins, 2 cephalosporins, and gentamicin to rabbits over a 24 hour period. Samples of serum and aqueous humor were obtained after the first and after the fifth dose of antibiotic. Of the agents studied, only methicillin in multiple doses gave therapeutic concentrations in the aqueous humor of normal rabbits. It is proposed that any future studies of intraocular penetration of antimicrobials be designed to include single and multiple doses in normal and infected eyes.
R M Kluge, and
T Zimmerman
January 2001,
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde,
R M Kluge, and
T Zimmerman
February 1955,
American journal of ophthalmology,
R M Kluge, and
T Zimmerman
April 1974,
American journal of ophthalmology,
R M Kluge, and
T Zimmerman
January 1986,
Transactions of the ophthalmological societies of the United Kingdom,
R M Kluge, and
T Zimmerman
October 1988,
Journal of pharmacobio-dynamics,
R M Kluge, and
T Zimmerman
January 1970,
American journal of veterinary research,
R M Kluge, and
T Zimmerman
January 2003,
Ophthalmic research,
R M Kluge, and
T Zimmerman
February 1990,
Nippon Ganka Gakkai zasshi,
R M Kluge, and
T Zimmerman
February 2001,
Experimental eye research,
R M Kluge, and
T Zimmerman
February 1982,
Archives of ophthalmology (Chicago, Ill. : 1960),
