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The cause of hyperphosphatemia in patients with tumoral calcinosis never been explained. We studied two related patients who had tumoral calcinosis and hyperphosphatemia and two normal controls to determine their renal tubular response to parathyroid hormone (PTH) and acetazolamide (ACZ). During baseline periods, the patients had abnormally low fractional excretion of phosphorus (FEP) despite their hyperphosphatemia. Values for patients were 0.114 and 0.128; for controls, values were 0.193 and 0.165. PTH caused an increase in FEP and urinary cAMP in both patients and controls. ACZ also increased FEP in both groups, and the effects of PTH and ACZ were additive, suggesting that patients with tumoral calcinosis have normal sensitivities to PTH and normal responses to ACZ. Levels of vitamin D metabolites in the patients were normal. We conclude that patients with tumoral calcinosis have a reduced ability to excrete phosphorus. This defect does not seem to be due to impaired PTH secretion, an abnormal phosphaturic response to this hormone, or a disturbance of vitamin D metabolism.
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
January 2015,
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
June 2014,
American journal of medical genetics. Part A,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
June 1987,
The Quarterly journal of medicine,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
July 1988,
The Journal of clinical endocrinology and metabolism,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
January 1977,
Annals of internal medicine,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
April 1977,
The Journal of pharmacology and experimental therapeutics,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
November 1972,
Annals of internal medicine,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
February 1984,
Revue du rhumatisme et des maladies osteo-articulaires,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
April 1995,
Bone,
E G Lufkin, and
D M Wilson, and
L H Smith, and
N J Bill, and
H F DeLuca, and
T P Dousa, and
F G Knox
September 1978,
Kidney international,
