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Female adult Wistar rats were fed with a diet containing 0.05% hexachlorobenzene (HCB) or its metabolites, pentachlorobenzene (PCB) and pentachlorphenole (PCP). These chlorinated aromatic hydrocarbons produced an increase in the liver cytochrome P-450 content in about the same degree, however, only the application of HCB showed an extremely high rise in the P-450 enzymatic activity expressed in terms of the O-dealkylation of 7-Ethoxycoumarine. No alteration was observed in the urinary porphyrin excretion in the PCB and PCP treated animals, whereas 60 days after the beginning of the HCB application a high level of porphyrins could be detected in the urine of the animals. It seems unlikely therefore that the HCB metabolites (PCB and PCP) are porphyrogenic agents. In addition, although induction of the liver cytochrome P-450 system was observed after PCP pretreatment of the rats over a period of 40 days, the consequent application of HCB did not influence the establishment of the experimental porphyria.
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
January 1982,
Zeitschrift fur Gastroenterologie,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
January 1981,
Arzneimittel-Forschung,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
December 1982,
Zeitschrift fur Gastroenterologie,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
August 1977,
Archives for dermatological research = Archiv fur dermatologische Forschung,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
January 1985,
Arzneimittel-Forschung,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
January 1985,
Arzneimittel-Forschung,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
February 1961,
Archives of biochemistry and biophysics,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
June 1977,
Experientia,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
January 1976,
Arzneimittel-Forschung,
G Goerz, and
W Vizethum, and
K Bolsen, and
T Krieg, and
R Lissner
December 1975,
MMW, Munchener medizinische Wochenschrift,
