Biomaterial Database

Progressive retinal atrophy in the Samoyed. 1980

P F Dice

In Samoyeds 2-5 years old, progressive retinal atrophy was evidenced ophthalmoscopically by peripheral tapetal hyperreflectivity and vascular attenuation, with marked generalized retinal thinning and vascular attenuation at 5-8 years. Pupil response remained active until late in the disease. Histologically, early retinal development was normal, with lesion onset paralleling that of ERG abnormalities. Pedigree examination and test-breeding results were compatible with simple autosomal recessive inheritance.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D012162	Retinal Degeneration	A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)	Degeneration, Retinal,Degenerations, Retinal,Retinal Degenerations
D004283	Dog Diseases	Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.	Canine Diseases,Canine Disease,Disease, Canine,Disease, Dog,Diseases, Canine,Diseases, Dog,Dog Disease
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia