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A 69-year-old heavily virilized woman with an androgen-producing tumor of the right ovary is described. After tumor removal, plasma testosterone levels fell from 5 to less than 0.6 ng/ml. Serum gonadotropins were low prior to surgery and rose to high levels postoperatively. Histologic examination of the right ovary revealed a hilus cell tumor. Incubation of small specimens of tumor tissue for 2 hours in oxygenated Krebs bicarbonate buffer containing glucose and bovine serum albumin yielded a release of predominantly testosterone and androstenedione into the medium. Human chorionic gonadotropin (hCG) added to the medium had no effect on steroid release. Incubation of tumor tissue in vitro may provide a useful functional adjuvant to the morphologic characterization of hormone-producing ovarian tumors. Such combined studies may increase our knowledge of the much-debated histogenesis of these tumors.
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
February 1998,
Acta obstetricia et gynecologica Scandinavica,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
October 1981,
Obstetrics and gynecology,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
April 1960,
Obstetrics and gynecology,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
January 1968,
Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
February 1957,
American journal of obstetrics and gynecology,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
October 1978,
Obstetrics and gynecology,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
August 1988,
Ceskoslovenska patologie,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
January 1956,
Quarterly bulletin. Northwestern University (Evanston, Ill.). Medical School,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
February 1991,
Archives of pathology & laboratory medicine,
P O Janson, and
L Hamberger, and
J E Damber, and
B Dennefors, and
F Knutson
April 1968,
American journal of obstetrics and gynecology,
