Biomaterial Database

[Ornithine decarboxylase activity in malignant tumors]. 1980

S P Siatkin, and T T Berezov

Activity of ornithine decarboxylase was studied in transplantable hepatomas G-27, G-22, G-61, G-60, G-48, G-46, in liver tissues of tumor-bearing and intact animals as well as in liver tissue during hepatocarcinogenesis and after repeated administration of nitrose piperidine. The rate of ornithine decarboxylation was distinctly increased in hepatomas G-27, G-60, G-46 and G-48 as compared with liver tissue of tumor-bearing and intact animals. The enzymatic activity in hepatomas G-22 and G-61 was similar to the activity found in liver tissue of intact animals. In liver tissue of tumor-bearing animals the enzyme activity was significantly increased only in hepatoma 22. Repeated administration of nitrose piperidine did not affect the ornithine decarboxylase activity in rat liver tissue. The carcinogenesis, caused by nitrosamine effect, increased distinctly the enzymatic activity in rat liver tissue up to the moment of the primary hepatomas development.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008114	Liver Neoplasms, Experimental	Experimentally induced tumors of the LIVER.	Hepatoma, Experimental,Hepatoma, Morris,Hepatoma, Novikoff,Experimental Hepatoma,Experimental Hepatomas,Experimental Liver Neoplasms,Hepatomas, Experimental,Neoplasms, Experimental Liver,Experimental Liver Neoplasm,Liver Neoplasm, Experimental,Morris Hepatoma,Novikoff Hepatoma
D008809	Mice, Inbred C3H	An inbred strain of mouse that is used as a general purpose strain in a wide variety of RESEARCH areas including CANCER; INFECTIOUS DISEASES; sensorineural, and cardiovascular biology research.	Mice, C3H,Mouse, C3H,Mouse, Inbred C3H,C3H Mice,C3H Mice, Inbred,C3H Mouse,C3H Mouse, Inbred,Inbred C3H Mice,Inbred C3H Mouse
D009368	Neoplasm Transplantation	Experimental transplantation of neoplasms in laboratory animals for research purposes.	Transplantation, Neoplasm,Neoplasm Transplantations,Transplantations, Neoplasm
D009602	Nitrosamines	A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.	Nitrosamine
D009955	Ornithine Decarboxylase	A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.	Ornithine Carboxy-lyase,Carboxy-lyase, Ornithine,Decarboxylase, Ornithine,Ornithine Carboxy lyase
D010880	Piperidines	A family of hexahydropyridines.
D011073	Polyamines	Amine compounds that consist of carbon chains or rings containing two or more primary amino groups.	Polyamine
D002262	Carboxy-Lyases	Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.	Carboxy-Lyase,Decarboxylase,Decarboxylases,Carboxy Lyase,Carboxy Lyases
D004052	Diethylnitrosamine	A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.	Nitrosodiethylamine,N-Nitrosodiethylamine,N Nitrosodiethylamine