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The interferon-inducer, polyinosinate . polycyctidylate [Poly (I) . Poly (C)] stimulated both prostaglandin E (PGE) and hyaluronic acid (HA) production by human cultured synovial fibroblasts. Increased accumulation of PGE in the medium was noted within 3 hours of culture, while accumulation of HA was observed only after a 24 hour lag period. The stimulation of PGE and HA production by Poly (I) . Poly (C) was prevented by aspirin and indomethacin. Human interferon was also effective in stimulating both PGE and HA production. Concomitant addition of cortisol to culture medium abrogated the stimulatory effect of Poly (I) . Poly (C) and interferon on both PGE and HA production. Exogenous PGE2, however, overcame the inhibitory effect of cortisol on HA production. The present results suggest that the stimulatory effect of both interferon and Poly (I) . Poly (C) on HA production may be mediated by PGE. Prostaglandins may thus play a role in the inflammatory process associated with viral infections.
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
February 1964,
Nature,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
January 1979,
Virology,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
February 1986,
Arthritis and rheumatism,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
May 1970,
Applied microbiology,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
January 1981,
Voprosy virusologii,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
November 1980,
Nature,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
January 1980,
Annals of the New York Academy of Sciences,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
June 1983,
Arthritis and rheumatism,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
March 1975,
Biochemical and biophysical research communications,
M Yaron, and
I Yaron, and
C Wiletzki, and
U Zor
December 1982,
The Journal of general virology,
