Biomaterial Database

1-2 Dimethylhydrazine induced colonic tumours in rats. 1980

F Roussel, and R Laumonier, and J Tayot

1-2 dimethylhydrazine was injected subcutaneously on a weekly basis of 15 mg/kg, during periods ranging from one to twenty-eight weeks into five hundred Wistar rats. Glandular-mucin depletion appears as early as the second injection (sulfomucins disappear). From the sixth week, one observes dysplasia; if the animals are allowed to survive for a longer period all will develop colonic carcinomas, which were found mainly in the left colon. This dysplasia, which is first mild, then moderate, is finally severe in rat mucosa or in the area of polyps. Dysplastic polyps become less frequent when carcinomas increase in number and in size. The average length of survival after cessation of the exposure is inversely proportional to the total dose administered. The glandular mucin depletion-dysplasia-carcinoma sequence characterizes the types of formation of 1-2 DMH induced colonic carcinomas. One of the striking features is the early appearance of this sequence.

UI	MeSH Term	Description	Entries
D007417	Intestinal Polyps	Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.	Intestinal Polyp,Polyp, Intestinal,Polyps, Intestinal
D008763	Methylhydrazines	Hydrazines substituted by one or more methyl groups in any position.
D009374	Neoplasms, Experimental	Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.	Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D011230	Precancerous Conditions	Pathological conditions that tend eventually to become malignant.	Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D003110	Colonic Neoplasms	Tumors or cancer of the COLON.	Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon
D004127	Dimethylhydrazines	Hydrazines substituted with two methyl groups in any position.	Dimethylhydrazine
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus