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Immunoreactive methionine enkephalin and beta-endorphin were sought by serial dilution of tissue extracts and assay of chromatographic fractions in non-endocrine tumour tissue from three patients with the ectopic adrenocorticotrophin syndrome associated with carcinoid tumours and in normal lung tissue and thymic tissue from a patient with myasthenia gravis. In all cases serial dilution of extracts showed parellelism to standard radioimmunoassay curves. The two peptides were found in high concentration in the three tumours but were undetectable in the control tissues. In a single case tested the methionine enkephalin concentration in a vein draining the tumour was twice that in a peripheral vein. In view of their profound effect on behaviour in animals and potent analgesic activity in animals and man the ectopic secretion of methionine enkephalin and beta-endorphin may modify the clinical features of a wide variety of tumours and produce some of the diverse clinical syndromes associated with malignancy.
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
April 1980,
British medical journal,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
April 1980,
British medical journal,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
January 1985,
Uspekhi fiziologicheskikh nauk,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
March 1985,
Neuroscience letters,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
December 1978,
Japanese journal of pharmacology,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
January 1988,
Life sciences,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
August 1979,
Biochimica et biophysica acta,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
January 1985,
Endocrinology,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
August 1979,
Brain research,
P T Pullan, and
V Clement-Jones, and
R Corder, and
P J Lowry, and
G M Rees, and
L H Rees, and
G M Besser, and
M M Macedo, and
A Galvao-Teles
March 1995,
Brain research,
