The ependymal and supraependymal cells of the armadillo infundibulum (INF) were investigated by correlative histochemistry, scanning and transmission electron microscopy. Eighteen armadillos (8 adult females, 6 adult males, 2 immature females and 2 immature males) were examined. The following supraependymal elements were observed: (a) individual pleiomorphic cells made up of neurons, macrophages, and astrocytic-glial cells; (b) numerous spherical blebs of various sizes occurring singly or in clusters; (c) axons, traversing the surface alone or in association with macrophages and other SEC; (d) multicellular clusters containing SEC, macrophages, axons and other cell types. There were neurosecretory axons or blebs on and below the ependymal cell layer and a unique arrangement of multipolar cells and their processes, traversing the INF floor for several millimeters. The presence of neurosecretory axons at the INF ventricular surface, spherical blebs and SEC in contact with one another via long filaments or vast networks of smaller axons on the surface and numerous macrophages in close apposition to possible metabolic and transport sites give evidence of organized activity in a regulatory system.