Biomaterial Database

Enhancement of epoxide hydratase activity in rat lung, kidney and liver by dietary antioxidants. 1980

R Kahl

Enhancement of pulmonary epoxide hydratase activity in the rat was obtained by feeding a diet which contained 0.5% ethoxyquin (EQ) or 3,5-di-tert-butyl-4-hydroxytoluene (BHT). The enhancement was less marked (1.6-fold) than in the liver, where a 2-4-fold enhancement of enzyme activity was found after feeding 0.5% antioxidant. A minimal enhancing concentration of 0.1% EQ or BHT in food was established for hepatic epoxide hydratase. In kidney microsomes, elevation of enzyme activity was obtained with 0.5% EQ (1.8-fold), but not with 0.5% BHT. No concomitant increase of cytochrome P-450 content and of aryl hydrocarbon hydroxylase activity was found in the tissues studied.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008297	Male		Males
D008861	Microsomes	Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)	Microsome
D002084	Butylated Hydroxytoluene	A di-tert-butyl PHENOL with antioxidant properties.	Butylhydroxytoluene,2,6-Bis(1,1-dimethylethyl)-4-methylphenol,2,6-Di-t-butyl-4-methylphenol,2,6-Di-tert-butyl-4-methylphenol,2,6-Di-tert-butyl-p-cresol,4-Methyl-2,6-ditertbutylphenol,BHT,Di-tert-butyl-methylphenol,Dibunol,Ionol,Ionol (BHT),2,6 Di t butyl 4 methylphenol,2,6 Di tert butyl 4 methylphenol,2,6 Di tert butyl p cresol,4 Methyl 2,6 ditertbutylphenol,Di tert butyl methylphenol,Hydroxytoluene, Butylated
D004851	Epoxide Hydrolases	Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.	Epoxide Hydrase,Epoxide Hydrases,Epoxide Hydratase,Epoxide Hydratases,Epoxide Hydrolase,9,10-Epoxypalmitic Acid Hydrase,Microsomal Epoxide Hydrolase,Styrene Epoxide Hydrolase,9,10 Epoxypalmitic Acid Hydrase,Acid Hydrase, 9,10-Epoxypalmitic,Epoxide Hydrolase, Microsomal,Epoxide Hydrolase, Styrene,Hydrase, 9,10-Epoxypalmitic Acid,Hydrase, Epoxide,Hydrases, Epoxide,Hydratase, Epoxide,Hydratases, Epoxide,Hydrolase, Epoxide,Hydrolase, Microsomal Epoxide,Hydrolase, Styrene Epoxide,Hydrolases, Epoxide
D005015	Ethoxyquin	Antioxidant; also a post-harvest dip to prevent scald on apples and pears.	1,2-Dihydro-6-Ethoxy-2,2,4-Trimethylquinoline,6-ETMDQ,6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline,Santoquin
D005520	Food Preservatives	Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.	Preservatives, Food
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia