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The activity of dopamine-beta-hydroxylase (DBH) in cerebrospinal fluid (CSF) from 59 psychiatric patients has been analyzed by a highly sensitive radio-enzymatic assay. There was no sex difference in DBH, but there was a significant positive correlation with age. Probenecid administration had no effect on CSF DBH. DBH in CSF correlated positively (r = 0.60) with the plasma enzyme. Among patients hospitalized for major depressive disorder, unipolar or bipolar, schizo-affective disorder, schizophrenia, alcoholism, or personality disorders there were no significant between-group differences. Among the patients with bipolar affective disorder, DBH activity from manic patients was significantly lower than that from depressed or euthymic patients. The results are discussed with reference to the theory that the amount of DBH in CSF may serve as an indicator of central noradrenergic activity.
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D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
May 1992,
No to hattatsu = Brain and development,
P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
January 1976,
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P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
December 1977,
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P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
October 1990,
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P Lerner, and
F K Goodwin, and
D P van Kammen, and
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W Lovenberg
March 1984,
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W Lovenberg
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Hypertension (Dallas, Tex. : 1979),
P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
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J C Ballenger, and
W Lovenberg
July 1984,
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P Lerner, and
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D P van Kammen, and
R M Post, and
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J C Ballenger, and
W Lovenberg
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P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
June 1982,
Clinical chemistry,
P Lerner, and
F K Goodwin, and
D P van Kammen, and
R M Post, and
L F Major, and
J C Ballenger, and
W Lovenberg
May 1980,
Brain research,
