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Effect of litter size at birth on lactation in mice. 1980

E J Eisen, and J Nagai, and H Bakker, and J F Hayes

The relative influence of litter size at birth and dam body weight at parturition on lactational performance was determined with five among-line crossfostering experiments involving 17 populations of mice. Included were lines selected for postweaning growth and maternal performance, and unselected controls. Twelve-day litter weight of a crossfostered litter standardized to six or eight pups was used as the criterion of lactational performance. Litter size at birth had a small positive correlation with 12-day litter weight when pooled within lines in each crossfostering experiment (.06 to .30, with mean of .17). The correlation between dam body weight at parturition and her crossfostered 12-day litter weight was consistently higher (.13 to .51, with mean of .35). Litter size was positively correlated with dam body weight at parturition (.33 to .56, with mean of .47). The partial correlation between litter size and 12-day litter weight, with dam body weight at parturition held constant, was reduced (-.07 to .18, with mean of .02) compared to the simple correlation. Multiple regression analyses indicated that dam body weight at parturition consistently accounted for more of the variation in 12-day litter weight than litter size. The data provide no evidence to support the hypothesis that increased fetal number or mass results in a greater lactational output by the dam.

UI MeSH Term Description Entries
D007774 Lactation The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN. Lactation, Prolonged,Milk Secretion,Lactations, Prolonged,Milk Secretions,Prolonged Lactation,Prolonged Lactations
D008098 Litter Size The number of offspring produced at one birth by a viviparous animal. Litter Sizes,Size, Litter,Sizes, Litter
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

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