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Adverse reactions to roentgenographic contrast media (RCM) are associated with the release of mediators including complement components (anaphylatoxins), histamine and serotonin. In an in vitro study of platelets and leukocytes from 20 healthy individuals, RCM-induced release of granules from basophils and platelets was correlated with the release of histamine and serotonin respectively. The release of histamine from basophils was augmented in the presence of exogenous complement; in contrast, the release of serotonin from platelets was not dependent on the addition of exogenous complement. Although individual differences were noted, iothalamate most effectively released serotonin, whereas diatrizoate most effectively released histamine.
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
December 1961,
The American journal of roentgenology, radium therapy, and nuclear medicine,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
October 1954,
Schweizerische medizinische Wochenschrift,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
January 1982,
Acta radiologica: diagnosis,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
April 2005,
Toxicology,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
January 1967,
Investigative radiology,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
January 1971,
Bruns' Beitrage fur klinische Chirurgie,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
June 1963,
Minerva radiologica, fisioterapica e radiobiologica,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
May 1985,
The Journal of investigative dermatology,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
April 1978,
Clinical and experimental immunology,
M J Fritzler, and
J Ring, and
C M Arroyave, and
E M Tan
February 1979,
Zeitschrift fur Immunitatsforschung. Immunobiology,
