Biomaterial Database

Permeability of intestinal capillaries to endogenous macromolecules. 1980

D N Granger, and A E Taylor

Steady-state lymphatic and plasma protein concentration (CL and CP) and lymph flows were analyzed in an autoperfused cat ileum preparation at venous outflow pressures of 0, 10, 20, and 30 mmHg. Albumin and nine endogenous protein fractions were analyzed in lymph and plasma by polyacrylamide gradient gel electrophoresis. The osmotic reflection coefficient (sigma d = 1--CL/CP when CL/CP is no longer influenced by capillary filtration rate. The sigma d values acquired increased as the molecular radius of the protein fraction increased. Permeability-surface area products were estimated for the various protein fractions by applying the acquired data to the Kedem-Katchalsky protein flux equation. A comparison of the permeability-surface area products at various venous pressures suggests a reduction in capillary surface area as venous pressure is increased to 20 and 30 mmHg. The results suggest that intestinal capillaries selectively restrict macromolecules to a greater degree than the continuous type of capillaries of many other organs.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D008433	Mathematics	The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Mathematic
D001798	Blood Proteins	Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.	Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D002196	Capillaries	The minute vessels that connect arterioles and venules.	Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002463	Cell Membrane Permeability	A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.	Permeability, Cell Membrane
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012709	Serum Albumin	A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.	Plasma Albumin,Albumin, Serum