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1 The content, uptake and storage of 5-hydroxytryptamine (5-HT) in platelets were determined in eight manic-depressive patients not on lithium (Li); in ten manic-depressive patients on Li; and in ten apparently normal persons as controls. 2 Platelets from the patients, whether or not on Li, contained less 5-HT than platelets from normal people. 3 5-HT uptake and storage by platelets from untreated patients were significantly lower than those of control subjects. 4 When patients had been on Li for 3 months or longer the diminished uptake and storage of 5-HT by their platelets were more than fully reversed. 5 Li added to platelet-rich plasma in vitro had no effect on the uptake of 5-HT by platelets.
G V Born, and
G Grignani, and
K Martin
May 1976,
British journal of pharmacology,
G V Born, and
G Grignani, and
K Martin
October 1974,
Experientia,
G V Born, and
G Grignani, and
K Martin
June 1961,
British journal of pharmacology and chemotherapy,
G V Born, and
G Grignani, and
K Martin
January 1971,
Acta medica Scandinavica. Supplementum,
G V Born, and
G Grignani, and
K Martin
January 1980,
Thrombosis research,
G V Born, and
G Grignani, and
K Martin
August 1957,
The Journal of physiology,
G V Born, and
G Grignani, and
K Martin
June 1959,
The Journal of physiology,
G V Born, and
G Grignani, and
K Martin
July 1971,
The Journal of pharmacy and pharmacology,
G V Born, and
G Grignani, and
K Martin
July 1966,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G V Born, and
G Grignani, and
K Martin
April 1975,
British journal of pharmacology,
