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The shape changes of red blood cells (RBCs) flowing in narrow glass capillaries have been studied by the use of two microscopes viewing the cells simultaneously at right angles along a horizontal and a vertical optical axis. The observations show that the primary mode of deformation of RBCs in a narrow capillary is a folding or bending about the longitudinal axis of the capillary rather than a compression and extension of the cells in the plane of the original disk, which has been suggested previously [10].
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