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We measured the single-breath diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), functional residual capacity (FRC), and residual volume (RV) in anesthetized male hamsters, rats, guinea pigs, and rabbits whose weights varied from 40 to 3,500 g. TLC (defined as an airway pressure of 25 cmH2O) was calculated by neon dilution. The DLCO was estimated by a modification of the single-breath method. There was a high correlation between body weight and our measurement of both the diffusing capacity and the lung volumes. No significant difference in DLCO was observed in rats when measured in different body positions, at airway pressures of 10 or 20 cmH2O, from FRC or RV, in male or female rats, or following hyperventilation.
J Takezawa, and
F J Miller, and
J J O'Neil
December 1972,
Journal of applied physiology,
J Takezawa, and
F J Miller, and
J J O'Neil
June 1975,
Journal of applied physiology,
J Takezawa, and
F J Miller, and
J J O'Neil
July 1979,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J Takezawa, and
F J Miller, and
J J O'Neil
April 2003,
Chest,
J Takezawa, and
F J Miller, and
J J O'Neil
January 1982,
Scandinavian journal of clinical and laboratory investigation. Supplementum,
J Takezawa, and
F J Miller, and
J J O'Neil
December 2001,
Clinics in chest medicine,
J Takezawa, and
F J Miller, and
J J O'Neil
May 1988,
The American review of respiratory disease,
J Takezawa, and
F J Miller, and
J J O'Neil
September 2017,
Respiratory care,
J Takezawa, and
F J Miller, and
J J O'Neil
January 1980,
Toxicology,
J Takezawa, and
F J Miller, and
J J O'Neil
January 1974,
Respiration; international review of thoracic diseases,
