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A 4-year-old mixed-breed spayed bitch was euthanatized after 2 1/2 months of progressive neurologic disease. Prototheca organisms were identified by histopathology, culture, and electron microscopy. Specific fluorescent antibody procedures revealed two species--Prototheca wickerhamii and Prototheca zopfii. Organisms and pyogranulomatous lesions were found in the brain, spinal cord, right eye, kidneys, and heart.
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