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In 21 hyperthyroid female patients studied on 29 occasions, high levels of red-cell 2,3-diphosphoglycerate (2,3-DPG) have been found (5.75 +/- 0.7 mM) which, compared to a euthyroid control group (4.88 +/- 0.4 mM), could not be accounted for by differences in haematocrit, haemoglobin or phosphataemia. A significant correlation was found (P less than 0.05) between serum thyroid hormones and the 2,3-DPG concentration in the hyperthyroid patients. Eight of these patients were reexamined after treatment and normalization of thyroid function, showed a regression to normal 2,3-DPG values (4.81 +/- 0.6 mM) which could not be attributed to variations in haematocrit, haemoglobin or phosphataemia either. We therefore deduce that the shift to the right in the haemoglobin oxygen dissociation curve observed in patients of this type may be due to an increase in the red-cell 2,3-DPG content.
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
April 1974,
Acta medica Scandinavica,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
November 1973,
British journal of haematology,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
May 1973,
The New England journal of medicine,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
January 1983,
Haematologica,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
August 1971,
British journal of haematology,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
April 1972,
Lancet (London, England),
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
July 1972,
Lancet (London, England),
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
April 1976,
Toxicology and applied pharmacology,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
January 1993,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J L Alvarez-Sala, and
M A Urbán, and
J J Sicilia, and
A J Diaz Fdez, and
F Fdez Mendieta, and
D Espinós
October 1974,
Acta medica Scandinavica,
