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First clinical results are reported of a new prostaglandin-E2-derivative (16-phenoxy-prostaglandin-E2-methylsulfonylamide = SHB 286) as abortifacient using the extraamniotic route of application. Upon investigation in animals this prostaglandin-E2-derivative proved to be more tissue-selective and more potent in inducing abortion than the naturally occurring prostaglandins. Prostaglandin SHB 286(50 or 100 microgram) was applicated to 31 patients for legal abortion and to 7 patients with a missed abortion. The mean instillation-abortion time was 14.2 and 13.7 h respectively. 96% of the patients had a complete or incomplete abortion after 24 hours. Severe local or systemic side effects did not occur and the patients did not need any further medication.
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
January 1973,
Advances in the biosciences,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
July 1979,
Archives of gynecology,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
September 1977,
Wiener medizinische Wochenschrift (1946),
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
June 1973,
Lancet (London, England),
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
April 1974,
Das Deutsche Gesundheitswesen,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
July 1979,
Archives of gynecology,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
December 1974,
Zeitschrift fur Geburtshilfe und Perinatologie,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
January 1980,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
July 1979,
Archives of gynecology,
U Gethmann, and
E Schuster, and
H O Hoppen, and
F Oberheuser
January 1973,
The Journal of obstetrics and gynaecology of the British Commonwealth,
