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Various cell types of the rat testis during pubescence, including germ, Sertoli, and Leydig cells, were partially enriched. The fractions were tested for the presence, binding, and secretion of H-Y antigen. The main results are: Immature germ cells are H-Y antigen-negative until the late diploid stages, and late primary spermatocytes or spermatids become positive; the somatic cells of the gonad are positive at all ages examined (18 days old to adulthood). Secretion of H-Y antigen is restricted to the Sertoli cell fraction. Binding of externally supplied antigen takes place on Leydig cells; the Sertoli cell surface will be saturated because of active secretion; there is no binding to germ cells. Thus, immature germ cells seem to be the only H-Y antigen-negative cells of the male organism, and the Sertoli cells seem to be the only ones to secrete H-Y antigen.
M T Zenzes, and
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I Aschmoneit, and
U Wolf
January 1980,
Human genetics,
M T Zenzes, and
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January 1981,
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M T Zenzes, and
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March 1978,
Cell,
M T Zenzes, and
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January 1984,
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M T Zenzes, and
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February 1985,
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M T Zenzes, and
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January 1985,
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M T Zenzes, and
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September 1988,
Proceedings of the National Academy of Sciences of the United States of America,
M T Zenzes, and
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January 1987,
Nature,
M T Zenzes, and
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January 1993,
Histopathology,
M T Zenzes, and
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I Aschmoneit, and
U Wolf
January 1992,
Andrologia,
