Biomaterial Database

25-hydroxycholecalciferol 1 alpha-hydroxylase activity in the kidney of the fetal, neonatal and adult guinea pig. 1980

E Fenton, and H G Britton

Homogenates of fetal, newborn and maternal kidney and placenta have been compared with homogenates of non-pregnant adult kidney for their ability to hydroxylate 25-hydroxycholecalciferol. The activity in the fetal kidney near term is similar to that in the mother and 4--5 times that in the non-pregnant adult. These differences from the non-pregnant adult are significant (p less than 0.05 and 0.1 fetus and newborn, respectively). Even higher levels are present in some newborn 12--24 h after birth, but these values fall towards the non-pregnant level in the following 21 days. Significant hydroxylating activity is present in the near-term placenta.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005260	Female		Females
D005333	Fetus	The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.	Fetal Structures,Fetal Tissue,Fetuses,Mummified Fetus,Retained Fetus,Fetal Structure,Fetal Tissues,Fetus, Mummified,Fetus, Retained,Structure, Fetal,Structures, Fetal,Tissue, Fetal,Tissues, Fetal
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D013250	Steroid Hydroxylases	Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthesis and metabolism.	Steroid Hydroxylase,Steroid Monooxygenases,Hydroxylase, Steroid,Hydroxylases, Steroid,Monooxygenases, Steroid
D015090	25-Hydroxyvitamin D3 1-alpha-Hydroxylase	A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).	25-Hydroxycholecalciferol 1-Hydroxylase,CYP27B1,Calcidiol 1-Monooxygenase,Cytochrome P-450 CYP27B1,25-Hydroxycholecalciferol-1-Hydroxylase,25-Hydroxyergocalciferol 1-alpha-Hydroxylase,25-Hydroxyvitamin D 1-alpha-Hydroxylase,25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase,25-Hydroxyvitamin D2 1-hydroxylase,1-alpha-Hydroxylase, 25-Hydroxyergocalciferol,1-alpha-Hydroxylase, 25-Hydroxyvitamin D,1-hydroxylase, 25-Hydroxyvitamin D2,25 Hydroxycholecalciferol 1 Hydroxylase,25 Hydroxyergocalciferol 1 alpha Hydroxylase,25 Hydroxyvitamin D 1 alpha Hydroxylase,25 Hydroxyvitamin D2 1 hydroxylase,25 Hydroxyvitamin D3 1 alpha Hydroxylase,Calcidiol 1 Monooxygenase,Cytochrome P 450 CYP27B1