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The influence of indomethacin (INDO) on the renal extraction of hippurate (EH) was studied in 12 conscious, newborn lambs divided into two groups based upon age. EH was measured before and after INDO (7.5 mg/kg i.v.) by collecting blood samples from both the abdominal aorta (opposite the renal artery) and renal vein (under fluoroscopy). In the youngest group (0--4 days, n = 5), control EH was 18 +/- 8% (mean +/- SE) and increased to 29 +/- 6% following INDO (p = NS). In the older animals (2--3 weeks, n = 7) control EH was 66 +/- 5% (p less than 0.001), compared to the 0--4-day-olds) and decreased to 57 +/- 4% following INDO (p less than 0.02). The results suggest that EH increases during the first weeks of life and that prostaglandins may play a role in regulating the tubular transport of hippurate.
E J Hoskins, and
S A Mendoza, and
W F Friedman
October 1980,
The Journal of pharmacology and experimental therapeutics,
E J Hoskins, and
S A Mendoza, and
W F Friedman
May 1990,
The American journal of physiology,
E J Hoskins, and
S A Mendoza, and
W F Friedman
October 1984,
Clinics in perinatology,
E J Hoskins, and
S A Mendoza, and
W F Friedman
March 1982,
Journal of applied physiology: respiratory, environmental and exercise physiology,
E J Hoskins, and
S A Mendoza, and
W F Friedman
February 1976,
The Journal of clinical investigation,
E J Hoskins, and
S A Mendoza, and
W F Friedman
January 1977,
Biology of the neonate,
E J Hoskins, and
S A Mendoza, and
W F Friedman
January 1976,
Acta biologica et medica Germanica,
E J Hoskins, and
S A Mendoza, and
W F Friedman
February 1981,
American journal of obstetrics and gynecology,
E J Hoskins, and
S A Mendoza, and
W F Friedman
January 1985,
Peptides,
E J Hoskins, and
S A Mendoza, and
W F Friedman
January 1978,
The Journal of endocrinology,
