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Prazosin kinetics were studied in 8 hypertensive patients (4 male and 4 female) with normal renal function. Intravenous data showed a 3-phase distribution. As a result, a linear 3-compartment model with elimination from the central compartment was proposed to describe the drug kinetics. Prazosin disappeared from plasma with a terminal half-life t1/2 of about 3 hr and had a central distribution volume of about 0.18 1/kg. Only a negligible fraction of the dose was found unchanged in urine. The oral data showed that, of the 2-mg dose, about 1 mg was effectively absorbed. This fraction was almost entirely absorbed in 2 hr. Absorption kinetics were apparently linear with a t1/2 of about 30 min.
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
October 1981,
Clinical pharmacology and therapeutics,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
February 1979,
The Journal of the Association of Physicians of India,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
December 1977,
Modern medicine of Asia,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
June 1989,
Cardiovascular drugs and therapy,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
August 1977,
The Medical journal of Australia,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
November 1975,
Postgraduate medicine,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
July 1981,
Polskie Archiwum Medycyny Wewnetrznej,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
June 1981,
Clinical pharmacology and therapeutics,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
January 1992,
Medicinski pregled,
N P Chau, and
B L Flouvat, and
E Le Roux, and
M E Safar
October 1990,
American journal of hypertension,
