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Gastric mucosal blood flow in dogs was estimated by radioactive labelled microspheres after SPV. The measurements were taken before and after gastric acid stimulation. The results show that under physiologic conditions a stimulation of gastric acid secretion is associated with an increased mucosal blood flow. After SPV, mucosal blood flow is increased, although it is known that gastric acid secretion is decreased. After histamine our results indicate a reversal of the effects of SPV into physiologic ranges. This observation is contrary to the generally accepted view that stimulation of acid secretion always is associated with an increase in gastric mucosal blood flow.
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