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Paraquat, bipyridilium herbicide know to cause pulmonary fibrosis, was injected IP into rats. The rate of synthesis of collagen by lung minces from these and control rats was evaluated by measuring the rate of synthesis of hydroxyproline, a specific marker for collagen in lung. Synthesis was measured by incubating lung minces with radioactive proline for various amounts of time, after which proline specific activity and labeled hydroxyproline were determined. The size of the proline pool within the lung minces was significantly elevated in minces from rats that had been injected with paraquat, thus causing the specific activity of the [3H]proline precursor to be lower in these lungs than in those from control animals. Lung minces from rats administered paraquat made more collagen than did those from uninjected controls. The actual increase in rate of collagen synthesis correlated well with other independent estimates of paraquat-induced damage to the lungs.
D B Greenberg, and
S A Lyons, and
J A Last
January 2022,
Antioxidants (Basel, Switzerland),
D B Greenberg, and
S A Lyons, and
J A Last
January 1987,
Journal of toxicology and environmental health,
D B Greenberg, and
S A Lyons, and
J A Last
March 2010,
Toxicology letters,
D B Greenberg, and
S A Lyons, and
J A Last
October 2005,
Osteoarthritis and cartilage,
D B Greenberg, and
S A Lyons, and
J A Last
September 1990,
Biomedical and environmental sciences : BES,
D B Greenberg, and
S A Lyons, and
J A Last
August 1978,
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D B Greenberg, and
S A Lyons, and
J A Last
June 1988,
Toxicology and applied pharmacology,
D B Greenberg, and
S A Lyons, and
J A Last
July 2007,
Free radical biology & medicine,
D B Greenberg, and
S A Lyons, and
J A Last
June 1988,
Toxicology and applied pharmacology,
D B Greenberg, and
S A Lyons, and
J A Last
July 1993,
The American journal of physiology,
