Biomaterial Database

[Permeability of bilayer lipid membranes to nystatin]. 1980

E K Alekberli, and V P Topaly

The permeability coefficient of BLM to nystatin was measured as function of cholesterol content of membrane and KCL concentration of aqueous medium. The data obtained were used to demonstrate that leakage of metabolites from microorganisms cytoplasm induced by nystatin may be a result of "two-sided" effect of polyene. This eliminates the known contradication between "two-sided" formation of pores in BLM by nystatin and its "one-sided" biological effect.

UI	MeSH Term	Description	Entries
D008051	Lipid Bilayers	Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.	Bilayers, Lipid,Bilayer, Lipid,Lipid Bilayer
D009761	Nystatin	Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.	Fungicidin,Mycostatin,Nilstat,Nystatin A1,Nystatin A2,Nystatin A3,Nystatin G,Stamicin,Stamycin
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D011189	Potassium Chloride	A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.	Slow-K,Chloride, Potassium
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol