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The activity of the lipoperoxide-detoxicating enzyme glutathion--peroxidase II (GP II) in the blood of intact mammals predisposed to atherogenesis (rabbits, mini-pigs, men) is considerably less as compared to the species resistant to atherosclerosis development (rats). Hypercholesterolemia produces an abrupt decrease in GP II activity in the whole blood, plasma and formed elements (red cells, platelets) of the blood of mammals susceptible to atherosclerosis, while in the atherogenesis-resistant species (rats) the activity of the enzyme remains unchanged in spite of a considerable rise in the cholesterol blood content. In the course of the development of mini-pigs, the decreased cholesterol blood content is associated with a respective increase in the activity of GP II and lowered content of the primary and secondary products of lipid peroxidation in the blood of adult animals. The role of decreased activity of the enzymatic systems involved in lipoperoxide detoxication in the pathogenesis of atherosclerosis is discussed.
V Z Lankin, and
A K Tikhaze
January 1977,
Acta veterinaria Scandinavica,
V Z Lankin, and
A K Tikhaze
January 1986,
Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum,
V Z Lankin, and
A K Tikhaze
March 1989,
Archives of disease in childhood,
V Z Lankin, and
A K Tikhaze
September 1999,
Cancer letters,
V Z Lankin, and
A K Tikhaze
January 2001,
Veterinary research,
V Z Lankin, and
A K Tikhaze
January 1995,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
V Z Lankin, and
A K Tikhaze
October 2007,
Biological chemistry,
V Z Lankin, and
A K Tikhaze
April 1975,
Veterinariia,
V Z Lankin, and
A K Tikhaze
April 1987,
Clinical chemistry,
V Z Lankin, and
A K Tikhaze
February 1984,
Klinische Wochenschrift,
