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Lipid peroxidation (hydroperoxides and antioxidant activity) and lipid composition in liver homogenates and in its mitochondrial, microsomal and nuclear fractions were studied after 15--120 minutes of liver warm ischemia. Pronounced enhancement of lipid peroxidation during ischemia was seen in all subcellular fractions, particularly in the mitochondrial one. The results are consistent with low resistance of the liver and specifically its mitochondria to ischemia. Activation of lipid peroxidation corresponded with changes in the lipid composition. Decrease in the level of total and readily oxidizable lipids (cardiolipin) and accumulation of poorly oxidizable phospholipids (sphingomyelin) and highly toxic lysophosphatides were recorded. The evidence obtained suggests a role for lipid peroxidation in the pathogenesis of ischemic injuries to the liver.
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
November 1965,
Enzymologia,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
April 1981,
Biokhimiia (Moscow, Russia),
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
March 1988,
Chemical & pharmaceutical bulletin,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
November 1964,
Nutrition reviews,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
December 1969,
Indian journal of biochemistry,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
January 1988,
The International journal of biochemistry,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
January 1989,
The International journal of biochemistry,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
August 1972,
Biochimica et biophysica acta,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
January 1972,
Journal of gerontology,
L B Dudnik, and
M V Bilenko, and
A V Alesenko, and
L D Slesareva, and
E B Burlakova
September 1988,
Toxicology letters,
