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Changes occurring in the cell membrane of nondividing cells of Micrococcus lysodeikticus disIIp+ grown in the presence of the mucopeptide synthesis inhibitor D-cycloserine include (a) an increae in the relative amount of diphosphatidylglycerol with a concomitant decrease in the relative content of phosphatidylglycerol, (b) a small increase in the relative palmitic acid content of phosphatidylinositol, and (c) leakage of membrane components into the growth medium. Growth of the organism in the presence of both D-cycloserine and D-alanine (which prevents the effects of D-cycloserine on cell division and mucopeptide synthesis) prevents the above changes in the cell membrane, demonstrating that secondary damage to the cell membrane can occur as a rsult of inhibition in mucopeptide synthesis. Growth of the organism in the presence of D-cycloserine and pantoyl lactone prevents the leakage of membrne components and cell division inhibition. Possible relationships of these changes to cell division are discussed.
J H Johnson, and
E A Grula
January 1976,
Biochimie,
J H Johnson, and
E A Grula
September 1971,
Biochemical and biophysical research communications,
J H Johnson, and
E A Grula
April 1972,
Canadian journal of microbiology,
J H Johnson, and
E A Grula
June 1974,
FEBS letters,
J H Johnson, and
E A Grula
May 1980,
Journal of bacteriology,
J H Johnson, and
E A Grula
March 1957,
Nature,
J H Johnson, and
E A Grula
October 1972,
Biochimica et biophysica acta,
J H Johnson, and
E A Grula
March 1976,
European journal of biochemistry,
J H Johnson, and
E A Grula
April 1968,
Biochimica et biophysica acta,
J H Johnson, and
E A Grula
November 1967,
Canadian journal of microbiology,
