Biomaterial Database

Secretion of growth hormone and cortisol in obese subjects with asymptomatic reactive hypoglycemia. 1980

M Solter, and M Sekso

Secretion of growth hormone and cortisol during 6-hour glucose tolerance test was investigated in obese subjects with asymptomatic reactive hypoglycemia (n = 27), obese controls (n = 22) and nonobese individuals (n = 18). Asymptomatic reactive hypoglycemia was defined as the presence of blood glucose value(s) of 40 mg/dl and below in the posthyperglycemic period of the test with no related symptoms. Growth hormone and cortisol levels following glucose nadir were significantly higher in obese asymptomatic hypoglycemics than in obese controls. Specific post-nadir increment (delta growth hormone) was higher in hypoglycemic (6.41 +/- 0.48/Mean +/- SE/) than in nonhypoglycemic obese subjects (1.04 +/- 0.28 ng/ml). Similar difference was found for delta cortisol (8.48 +/- 1.1 vs. -0.81 +/- 0.63 microgram/dl). In contrast to growth hormone, significant inverse proportion was found between delta cortisol and blood glucose nadir (i.e. the lower glucose nadintrols. Cortisol response seems to be more important in the diagnosis of previous hypoglycemic condition. Results suggest that obese subjects with asymptomatic reactive hypoglycemia are similar to manifest reactive hypoglycemics.

UI	MeSH Term	Description	Entries
D007003	Hypoglycemia	A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.	Fasting Hypoglycemia,Postabsorptive Hypoglycemia,Postprandial Hypoglycemia,Reactive Hypoglycemia,Hypoglycemia, Fasting,Hypoglycemia, Postabsorptive,Hypoglycemia, Postprandial,Hypoglycemia, Reactive
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D009765	Obesity	A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D005951	Glucose Tolerance Test	A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).	Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006854	Hydrocortisone	The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.	Cortef,Cortisol,Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-,11-Epicortisol,Cortifair,Cortril,Epicortisol,Hydrocortisone, (11 alpha)-Isomer,Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer,11 Epicortisol
D013006	Growth Hormone	A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.	Growth Hormone, Recombinant,Pituitary Growth Hormone,Recombinant Growth Hormone,Somatotropin,Somatotropin, Recombinant,Growth Hormone, Pituitary,Growth Hormones Pituitary, Recombinant,Pituitary Growth Hormones, Recombinant,Recombinant Growth Hormones,Recombinant Pituitary Growth Hormones,Recombinant Somatotropins,Somatotropins, Recombinant,Growth Hormones, Recombinant,Recombinant Somatotropin